Protein production from immortal cells grown in vivo

Details Protein production from immortal cells grown in vivo Protein production from immortal cells grown in vivo

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) C07K 16/00 (2006.01) C12N 5/02 (2006.01) C12N 5/16 (2006.01) C12N 15/13 (2006.01) C12N 15/62 (2006.01)

Patent

CA 2104787

2104787 9216645 PCTABS00016 Antibodies or other protein derived from a given species can be produced in a discordantly related host animal of choice by culturing a hybridoma or other immortal protein-producing cell line in the peritoneal cavity of the host animal, if both the humoral immune response and the cell-mediated immune response of the host animal are compromised. The humoral immune response can be compromised congenitally; so for example C3-deficient animals can be used. The cell-mediated immune response is preferably compromised by administering cyclosporin A. This enables human-derived antibodies to be produced in vivo and in general it allows the scaling up of in vivo production methods by using larger animals than mice, which are generally currently used.

Affiliated with

Also associated with

Rating

Protein production from immortal cells grown in vivo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Protein production from immortal cells grown in vivo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein production from immortal cells grown in vivo will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2070704