C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) C07H 21/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/04 (2006.01) C40B 40/08 (2006.01) C40B 40/10 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2615947
The present invention relates to the identification and use of protein expression profiles with clinical relevance to osteoarthritis (OA). In particular, the invention provides the identity of marker proteins whose expression is correlated with OA and OA progression. Methods and kits are described for using these protein expression profiles in the study and/or diagnosis of OA, in the determination of the degree of advancement of OA, and in the selection and/or monitoring of treatment regimens. The invention also relates to the screening of drugs that modulate expression of these proteins or nucleic acid molecules encoding these proteins, in particular for the development of disease-modifying OA agents.
L'invention concerne l'identification et l'utilisation de profils d'expression de protéine pertinents sur le plan clinique pour l'ostéoarthrite (OA). Plus précisément, l'invention concerne l'identité de protéines marqueurs dont l'expression est corrélée à OA et à une progression de OA. L'invention concerne également des procédés et des kits permettant d'utiliser ces profils d'expression de protéine dans l'étude et/ou le diagnostic de OA, dans la détermination du degré d'avancement de OA et dans la sélection et/ou la surveillance de schémas thérapeutiques. L'invention concerne également le criblage de médicaments modulant l'expression de ces protéines ou des molécules d'acides nucléiques codant ces protéines, notamment pour le développement d'agents de OA modifiant la maladie.
Gobezie Reuben
Krastins Bryan
Millett Peter J.
Sarracino David A.
Brigham And Women's Hospital Inc.
Robic
LandOfFree
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