Protein-protein from s. cerevisiae and methods of using same

Details Protein-protein from s. cerevisiae and methods of using same Protein-protein from s. cerevisiae and methods of using same

C - Chemistry, Metallurgy

12

N

C12N 15/10 (2006.01) C07K 14/395 (2006.01) C07K 16/16 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2365548

The invention provides complexes of at least two polypeptides from the yeast S. cerevisiae and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids encoding chimeric polypeptides and vectors and cells containing the same. Also provided are methods of identifying agents that disrupt polypeptide complexes, methods of identifying complex or polypeptide in a sample, and for removing the same, methods of determining altered expression of a polypeptide in a subject and methods of treating/preventing disorders involving altered levels of complex or polypeptide.

L'invention concerne des complexes d'au moins deux polypeptides de la levure S. cerevisiae, ainsi que des méthodes d'utilisation de ces complexes. Cette invention concerne également des complexes purifiés de deux polypeptides, notamment des complexes chimères, ainsi que des polypeptides chimères et des complexes de ceux-ci, des acides nucléiques codant pour des polypeptides chimères, et des vecteurs et des cellules contenant ceux-ci. L'invention concerne en outre des méthodes permettant d'identifier des agents qui provoquent la rupture de complexes polypeptidiques, des méthodes permettant d'identifier et d'éliminer un complexe ou un polypeptide dans un prélèvement, des méthodes pour définir l'expression modifiée d'un polypeptide chez un sujet, et enfin des méthodes de traitement/prévention de troubles faisant intervenir des niveaux modifiés d'un complexe ou d'un polypeptide.

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