G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C07K 1/00 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 17/00 (2006.01) C12N 15/00 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01)
Patent
CA 2371006
The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
L'invention concerne la découverte de nouvelles interactions protéine-protéine impliquées dans les voies physiologiques mammaliennes, dont les troubles ou les maladies physiologiques. Les troubles et les maladies physiologiques sont, part exemple, le diabète sucré insulino-dépendant, les troubles neurodégénératifs, tels que la maladie d'Alzheimer, et similaire. Ainsi, l'invention concerne des complexes de ces protéines et/ou de leurs fragments, des anticorps dirigés contre lesdits complexes, le diagnostic de troubles dégénératifs physiologiques (dont le diagnostic de la prédisposition au trouble et le diagnostic de la présence de ce dernier), le criblage de médicaments à la recherche d'agents qui modulent l'interaction des protéines décrites, et l'identification de protéines additionnelles dans la voie commune aux protéines décrites.
Bartel Paul L.
Heichman Karen
Gowling Lafleur Henderson Llp
Myriad Genetics Inc.
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