C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C07K 14/47 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 17/00 (2006.01) C07K 19/00 (2006.01) C12N 5/10 (2006.01) C12N 9/12 (2006.01) C12N 15/02 (2006.01) C12N 15/09 (2006.01) C12N 15/62 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12N 15/74 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)
Patent
CA 2396460
The present invention relates to the discovery of novel protein-protein interactions that are involved in mammalian physiological pathways, including physiological disorders or diseases. Examples of physiological disorders and diseases include non-insulin dependent diabetes mellitus (NIDDM), neurodegenerative disorders, such as Alzheimer's Disease (AD), and the like. Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of physiological generative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins described herein.
La présente invention concerne la découverte de nouvelles interactions entre protéines impliquées dans les voies physiologiques des mammifères, notamment des affections ou maladies physiologiques. Des exemples d'affections et de maladies physiologiques comprennent le diabète non insulo-dépendant (DNID), des affections neurodégénératives, telles que la maladie d'Alzheimer et similaire. Ainsi, la présente invention a trait à des complexes de ces protéines et/ou de leurs fragments, aux anticorps des complexes, au diagnostic des affections génératives physiologiques (y compris le diagnostic d'une prédisposition à cette affection et celui de l'existence de cette affection), le criblage par l'intermédiaire de médicaments d'agents qui modulent l'interaction des protéines décrites dans la présente invention et l'identification de protéines supplémentaires dans la voie commune auxdites protéines.
Bartel Paul L.
Cimbora Daniel M.
Heichman Karen
Gowling Lafleur Henderson Llp
Myriad Genetics Inc.
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