C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 1/00 (2006.01) A01K 67/00 (2006.01) A01K 67/027 (2006.01) A01K 67/033 (2006.01) C07K 14/00 (2006.01) C07K 14/47 (2006.01) C07K 17/00 (2006.01) C12N 5/00 (2006.01) C12N 5/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01)
Patent
CA 2358086
The present invention relates to the discovery of protein-protein interactions that are involved in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD). Thus, the present invention is directed to complexes of these proteins and/or their fragments, antibodies to the complexes, diagnosis of neurodegenerative disorders (including diagnosis of a predisposition to and diagnosis of the existence of the disorder), drug screening for agents which modulate the interaction of proteins described herein, and identification of additional proteins in the pathway common to the proteins describe herein.
La présente invention concerne la découverte d'interaction protéine-protéine impliquées dans la pathogenèse de troubles neurodégénératifs, notamment la maladie d'Alzheimer (MA). Ainsi, cette invention concerne des complexes de ces protéines et/ou de leurs fragments, des anticorps agissant contre ces complexes, le dépistage de troubles neurodégénératifs (y compris le dépistage de la prédisposition et de l'existence de troubles), le criblage de médicaments pour des agents qui modulent l'interaction des protéines précédemment décrites, ainsi que l'identification de protéines supplémentaires dans la voie commune des protéines précitées.
Bartel Paul L.
Roch Jean-Marc
Gowling Lafleur Henderson Llp
Myriad Genetics Inc.
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