Protein s functional assay

Details Protein s functional assay Protein s functional assay

G - Physics

01

N

G01N 33/86 (2006.01) G01N 33/68 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2432118

The invention relates generally to a new functional protein S assay and kit that is based on the ability of endogenous protein S to prolong clotting time. In the assay procedure, a test plasma sample is diluted with protein S deficient plasma, followed by the addition of purified or recombinant tissue factor (pTF or rTF), purified natural or synthetic phospholipid (pPL or sPL) and activated protein C (APC) or protein C activator (PCA). The clotting time is then measured and compared to a standard curve or a normal control.

L'invention concerne en règle générale un essai fonctionnel de protéine S et un kit reposant sur la capacité de la protéine S endogène à prolonger le temps de coagulation. Selon la procédure d'essai considérée, un échantillon de plasma test est dilué avec du plasma déficient en protéine S, et on ajoute ensuite un facteur de tissu purifié ou de recombinaison (pTF ou rTF), un phospholipide purifié naturel ou synthétique (pPL ou sPL) et de la protéine C activée (APC) ou bien un activateur de protéine C (PCA). L'étape suivante consiste à mesurer le temps de coagulation et à comparer ce temps avec une courbe type ou avec un témoin normal.

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