Protein scaffolds for antibody mimics and other binding...

Details Protein scaffolds for antibody mimics and other binding... Protein scaffolds for antibody mimics and other binding...

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) C07K 14/78 (2006.01) C07K 16/24 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2400058

Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in diagnostic methods and in methods for evolving novel compound-binding species and their ligands.

La présente invention concerne des protéines présentant un domaine fibronectine de type III portant au moins une boucle randomisée. L'invention concerne également des acides nucléiques codant de telles protéines et l'utilisation de telles protéines, d'une part pour le diagnostic, et d'autre part pour des procédures permettant de faire évoluer les espèces de liaison de composés de l'invention et leurs ligands.

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