Protein scaffolds for antibody mimics and other binding...

Details Protein scaffolds for antibody mimics and other binding... Protein scaffolds for antibody mimics and other binding...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) C07K 14/76 (2006.01) C07K 14/78 (2006.01) C07K 16/46 (2006.01) C12N 15/10 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) G01N 33/536 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2351346

Disclosed herein are proteins that include a fibronectin type III domain having at least one randomized loop. Also disclosed herein are nucleic acids encoding such proteins and the use of such proteins in methods for evolving novel compound-binding species and their ligands.

L'invention concerne des protéines qui contiennent un domaine de fibronectine de type III comportant au moins une boucle aléatoire. L'invention concerne également des acides nucléiques codant ces protéines, ainsi que l'utilisation de ces protéines dans des méthodes de développement de nouvelles espèces de liaison de composés, et leurs ligands.

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