Protein stabilization in solution

Details Protein stabilization in solution Protein stabilization in solution

A - Human Necessities

61

K

A61K 38/48 (2006.01) B65D 1/02 (2006.01)

Patent

CA 2525224

A material selected from the group consisting of: silica-coated glass, silicone-coated glass, poly-mers of non-cyclic olefins, cycloolefin polymers and cycloolefin/linear olefin copolymers; is advan-tageous as an inner wall material in a container which comprises (i) a wall portion and (ii) one or more closure portions not constituting part of the wall portion, and which contains a formula-tion of a protein having an amino-terminal -carboxyglutamic acid (Gla) domain with 9-12 Gla residues.

L'invention concerne un matériau choisi dans le groupe constitué par : du verre revêtu de silice, du verre revêtu de silicone, des polymères d'oléfines non cycliques, des polymères de cyclooléfines et des copolymères de cyclooléfines/oléfines linéaires. Le matériau selon l'invention peut être utilisé avantageusement en tant que matériau de paroi intérieure dans un conteneur constitué (i) d'une partie paroi et (ii) d'au moins une partie fermeture ne faisant pas partie intégrante de la partie paroi, ledit conteneur contenant une préparation de protéine comportant un domaine acide .gamma.-carboxyglutamique (Gla) amino-terminal contenant des résidus de Gla 9-12.

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