Protein sustaining undifferentiated stem cells as such

Details Protein sustaining undifferentiated stem cells as such Protein sustaining undifferentiated stem cells as such

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) C12N 5/0789 (2010.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/475 (2006.01)

Patent

CA 2479056

It has been successfully achieved to sustain stem cells (for example, hematopoietic stem cells) while holding the undifferentiated state and pluripotency by providing a polypeptide having a WIF domain (for example, WIF- 1) to the stem cells. This polypeptide preferably contains an EGF-like repeat too. It has been achieved by providing a polypeptide preferably having the WIF domain together with a stem cell survival factor such as SCF. Thus, it becomes possible to easily provide a large amount of stem cells (for example, hematopoietic stem cells) containing functional precursor cells. It also becomes possible to more efficiently transfer a gene into the stem cells. Because of being homogeneous and almost free from impurities, the stem cell composition can remarkably relieve the side effects (for example, infection) occurring in the conventional therapy with the use of hematopoietic stem cells.

Nous avons soutenu avec succès des cellules souches, par exemple, des cellules souches hématopoïétiques, tout en maintenant l'état non différentié et une activité thérapeutique multiple en apportant un polypeptide ayant un domaine WIF, (par exemple, WIF-1) aux cellules souches. Ce polypeptide contient de préférence une répétition de type EGF. La réussite vient du fait que l'on a apporté un polypeptide ayant de préférence le domaine WIF avec un facteur de survie d'une cellule souche, notamment SCF. Ainsi, il est possible d'apporter facilement un grande quantité de cellules souches (par exemple, des cellules souches hématopoïétiques) contenant des cellules précurseurs fonctionnelles. Il est également possible de transférer plus efficacement un gène dans les cellules souches. En raison de l'homogénéité et de l'exemption presque complète d'impuretés, la composition de cellules souches peut soulager considérablement les effets secondaires, (par exemple, l'infection) apparaissant dans une thérapie conventionnelle avec l'utilisation de cellules souches hématopoïétiques.

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