Protein targeting into hiv virions based on hiv-1 vpr fusion...

Details Protein targeting into hiv virions based on hiv-1 vpr fusion... Protein targeting into hiv virions based on hiv-1 vpr fusion...

C - Chemistry, Metallurgy

12

N

C12N 15/49 (2006.01) A61K 31/70 (2006.01) A61K 38/16 (2006.01) A61K 48/00 (2006.01) C07K 14/155 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 9/52 (2006.01) C12N 9/62 (2006.01) C12N 9/64 (2006.01) C12N 15/57 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2198621

The present invention relates to a Vpr protein, a Vpx protein or fragments thereof which permit the development of chimeric molecules that can be specifically targeted into the mature HIV-1 and HIV-2 virions to affect their structural organization and/or functional integrity, thereby resulting in gene therapy for HIV-1 and HIV-2 infections. The present invention also relates to Vpr/Vpx protein fragments, p6 protein, p6 protein fragment, or functional derivatives thereof which interfere with the native Vpr/Vpx incorporation into HIV-1 and HIV-2 virions. The present invention also relates to treatment of HIV-1 and HIV-2 infections based on the proteins of the present invention.

L'invention concerne une protéine Vpr, une protéine Vpx, ou certains de leurs fragments permettant la création de molécules chimériques qui peuvent être spécifiquement ciblées dans des virions matures de VIH-1 et VIH-2 pour désorganiser leur structure et/ou leur intégrité fonctionnelle, ce qui permet d'obtenir une thérapie génique contre les infections à VIH-1 et VIH-2. L'invention concerne aussi des fragments de protéines Vpr/Vpx, la protéine p6, un de ses fragments ou certains de leurs dérivés fonctionnels, qui interfèrent avec l'incorporation des Vpr/Vpx natives dans des virions de VIH-1 et VIH-2. Cette invention concerne enfin un traitement des infections à VIH-1 et VIH-2 grâce aux protéines décrites.

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