C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/00 (2006.01) A61K 38/43 (2006.01) A61K 39/00 (2006.01) C07K 14/00 (2006.01) C07K 14/16 (2006.01) C07K 19/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2354044
The present invention provides a protein transduction system comprising one or more fusion proteins that includes a transduction domain and a cytotoxic domain. The cytotoxic domain is specifically activated in a cell exhibiting a unique characteristic. Further provided are protein transduction domains that provide enhanced transduction efficiency. The protein transduction system effectively kills or injures cells infected by one or a combination of different pathogens or cells exhibiting unique characteristics such as high levels of heavy metals, DNA damage or uncontrolled cell division.
L'invention concerne un système de transduction de protéines qui comprend au moins une protéine hybride comportant un domaine de transduction et un domaine cytotoxique. Le domaine cytotoxique est spécialement activé dans une cellule présentant une caractéristique particulière. L'invention concerne également des domaines de transduction de protéines offrant une plus grande efficacité de transduction. Le système de transduction de protéines tue ou lèse de manière efficace les cellules infectées par un agent pathogène ou une combinaison d'agents pathogènes, et les cellules présentant des caractéristiques particulières, telles que de fortes teneurs en métaux lourds, un ADN endommagé ou une division cellulaire incontrôlée.
Sim & Mcburney
Washington University
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