C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 39/395 (2006.01) C07K 14/71 (2006.01) C07K 16/28 (2006.01) C07K 16/40 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2185656
Agonist antibodies are disclosed which bind to the extracellular domain of receptor protein tyrosine kinases pTKs, and thereby cause dimerization and activation of the intracellular tyrosine kinase domain thereof. The antibodies are useful for activating their respective receptor and thereby enabling the role of the tyrosine kinase receptor in cell growth and/or differentiation to be studied. Chimeric proteins comprising the extracellular domain of the receptor pTKs and an immunoglobulin constant domain sequence are also disclosed.
L'invention se rapporte à des anticorps agonistes qui se fixent au domaine extracellulaire des tyrosines kinases des proteines réceptrices (pTK), et provoquent ainsi une dimérisation et une activation du domaine intracellulaire des tyrosines kinases. Les anticorps sont utilisés pour activer leur récepteur respectif et par conséquent permettre l'étude du rôle du récepteur des tyrosines kinases dans la croissance et/ou la différentiation cellulaires. L'invention se rapporte également aux protéines chimères comprenant le domaine extracellulaire des pTK réceptrices et une séquence du domaine constant de l'immunoglobuline.
Bennett Brian D.
Goeddel David
Lee James M.
Matthews William
Tsal Siao Ping
Dennison Associates
Genentech Inc.
LandOfFree
Protein tyrosine kinase agonist antibodies does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Protein tyrosine kinase agonist antibodies, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Protein tyrosine kinase agonist antibodies will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1994683