Protein tyrosine kinase aryl and heteroaryl quinazoline...

C - Chemistry – Metallurgy – 07 – D

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C07D 239/94 (2006.01) A61K 31/505 (2006.01) A61K 31/517 (2006.01) A61K 31/535 (2006.01) A61K 31/5377 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2223016

This invention relates to a method for the selective treatment of cell growth and differentiation characterized by activity of the human epidermal growth factor receptor type 2 (HER2). More specifically, this invention relates to the use of substituted or unsubstituted mono- or bi-cyclic aryl, heteroaryl, cycloalkyl or heterocycloalkyl compounds of the formula: (See formula I) in selectively regulating cell growth. Pharmaceutical compositions useful for the selective treatment of cell growth and differentiation are also described.

Cette invention se rapporte à un procédé pour le traitement sélectif de la croissance et de la différenciation cellulaires caractérisées par une activité du récepteur du facteur de croissance épidermique humain de type 2 (HER2). Plus spécifiquement, cette invention se rapporte à l'utilisation de composés aryle, hétéroaryle, cycloalkyle ou hétérocycloalkyle, monocycliques ou bicycliques substitués ou insubstitués dans la régulation sélective de la croissance cellulaire. Des compositions pharmaceutiques utiles pour le traitement sélectif de la croissance et de la différenciation cellulaires sont également décrites.

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