Protein tyrosine phosphatase inhibitors and methods of use...

Details Protein tyrosine phosphatase inhibitors and methods of use... Protein tyrosine phosphatase inhibitors and methods of use...

C - Chemistry, Metallurgy

07

F

C07F 9/38 (2006.01) A61K 31/66 (2006.01) C07F 9/547 (2006.01)

Patent

CA 2586363

The present invention provides compounds of Formula (I) and Formula (II) that are useful for modulating the biological activity of the protein tyrosine phosphatase-1b (PTP1B) enzyme. Compounds of this invention can be used to treat diseases and/or conditions in which the PTP1B enzyme is a factor. Such diseases and/or conditions include, but are not limited to, Type 1 diabetes, Type 2 diabetes, inadequate glucose tolerance, insulin resistance, obesity, hyperlipidemia, hypertriglyceridemia, hypercholesterolemia, low HDL levels, atherosclerosis, vascular restenosis, inflammatory bowel disease, pancreatitis, adipose cell tumors, adipose cell carcinoma, liposarcoma, dyslipidemia, cancer, and neurodegenerative diseases.

L'invention concerne les composés représentés par la formule (1) et la formule (2), qui peuvent servir à moduler l'activité biologique de la protéine-tyrosine-phosphatase-1b (PTP1B). Les composés décrits peuvent être utilisés pour traiter les maladies et/ou les états dans lesquels l'enzyme PTP1B joue un rôle. Ces maladies et/ou états comprennent notamment, mais non exclusivement, le diabète de type 1, le diabète de type 2, les défauts de tolérance du glucose, la résistance à l'insuline, l'obésité, l'hyperlipidémie, l'hypertriglycéridémie, l'hypercholestérolémie, les faibles taux de HDL, l'athérosclérose, la resténose vasculaire, l'affection intestinale inflammatoire, la pancréatite, les tumeurs adipocytaires, les carcinomes adipocytaires, les liposarcomes, la dyslipidémie, les cancers, et les maladies neurodégénératives. (Formule 1).

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