Protein variant of the net1 locus

Details Protein variant of the net1 locus Protein variant of the net1 locus

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 38/17 (2006.01) C07K 14/47 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2324656

The invention relates to a novel protein product of the NET1 locus. The novel protein has transforming activity in the NIH3T3 focus-forming assay and is suitable as a point of attack for influencing carcinogenesis and treating cancer by therapy, as well as for influencing apoptosis. The cloned DNA also provides a possibility for diagnosing cancer since transcripts of the transforming protein can be detected in patient samples.

L'invention concerne un nouveau produit protéinique du locus NET1. La nouvelle protéine possède une activité de transformation dans le test de formation d'un foyer NIH3T3. La protéine est utilisée comme site d'action pour l'influence thérapeutique de la formation et du traitement d'un cancer, ainsi que pour l'influence de l'apoptose. L'ADN clonée offre en outre une possibilité de diagnostic du cancer, du fait qu'on peut déceler dans le matériau du patient le transcrit de la protéine transformée.

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