C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/435 (2006.01) C07K 16/46 (2006.01)
Patent
CA 2712182
The present invention provides proteinaceous binding molecules, in particular antibodies, having at least two variable domains. One variable domain binds to a target molecule of interest. At least one other variable domain comprises a purification tag suitable for purification of said proteinaceous binding molecule. The purification tag enables the convenient purification of the proteinaceous binding molecule with monovalent binding properties against the target molecule.
La présente invention porte sur des molécules de liaison protéiques, en particulier sur des anticorps, ayant au moins deux domaines variables. Un domaine variable se lie à une molécule cible d'intérêt. Au moins un autre domaine variable comprend un marqueur de purification approprié pour la purification de ladite molécule de liaison protéique. Le marqueur de purification permet la purification commode de la molécule de liaison protéique avec des propriétés de liaison monovalente vis-à-vis de la molécule cible.
Borden Ladner Gervais Llp
Morphosys Ag
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