Proteinaceous lipid-containing particles

Details Proteinaceous lipid-containing particles Proteinaceous lipid-containing particles

C - Chemistry, Metallurgy

12

N

C12N 7/04 (2006.01) A61K 9/50 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 39/385 (2006.01) A61K 47/42 (2006.01) A61K 49/00 (2006.01) C07K 14/005 (2006.01) C07K 14/11 (2006.01) C07K 14/145 (2006.01) C07K 14/16 (2006.01) C07K 14/705 (2006.01) C12N 5/10 (2006.01) C12N 9/00 (2006.01) C12N 15/33 (2006.01) C12N 15/86 (2006.01) C12N 15/87 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2107879

2107879 9218621 PCTABS00017 Proteinaceous, lipid-containing particles can be prepared by co-expressing in a host cell (i) a self-assembling protein moiety in circumstances where the protein assembles to form a core, which then buds off from the host cell, thereby acquiring a lipid envelope derived from the host cell membrane and (ii) a membrane-bound protein moiety, which becomes integrated in the lipid envelope. The particles have a wide variety of uses. They may be used as an antigen presentation system, or they may for example have site-specific targeting ability, fusogenic properties, enzymic activity, cytotoxic activity, diagnostic utility and/or pharmaceutical activity.

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