Proteinaceous pharmaceuticals and uses thereof

C - Chemistry – Metallurgy – 40 – B

Patent

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C40B 40/10 (2006.01)

Patent

CA 2622441

The present invention provides cysteine-containing scaffolds and/or proteins, expression vectors, host cell and display systems harboring and/or expressing such cysteine-containing products. The present invention also provides methods of designing libraries of such products, methods of screening such libraries to yield entities exhibiting binding specificities towards a taraget molecule. Further provided by the invention are pharmaceutical compositions comprising the cysteine-containing products of the present invention.

L'invention concerne des échafaudages contenant de la cystéine et/ou des protéines contenant de la cystéine, des vecteurs d'expression, des cellules hôte, et des systèmes de présentation renfermant et/ou exprimant ces produits contenant de la cystéine. L'invention concerne également des procédés permettant de créer des banques de ces produits, des procédés de criblage de ces banques permettant d'obtenir des entités présentant des spécificités de liaison vis-à-vis d'une molécule cible. L'invention concerne en outre des compositions pharmaceutiques comprenant lesdits produits contenant de la cystéine.

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