C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/095 (2006.01) A61K 39/40 (2006.01) A61K 49/00 (2006.01) A61K 51/10 (2006.01) C07K 14/22 (2006.01) C07K 16/12 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2215161
A highly conserved, immunologically accessible antigen at the surface of Neisseria meningitidis organisms. Immunotherapeutic, prophylactic and diagnostic compositions and methods useful in the treatment, prevention and diagnosis of Neisseria meningitidis diseases. A proteinase K resistant Neisseria meningitidis surface protein having an apparent molecular weight of 22 kDa, the corresponding nucleotide and derived amino acid sequences (SEQ ID NO:1, NO:3, NO:5, and NO:7: SEQ ID NO:2, NO:4, NO:6, and NO:8), recombinant DNA methods for the production of the Neisseria meningitidis 22 kDa surface protein, and antibodies that bind to the Neisseria meningitidis 22 kDa surface protein.
La présente invention concerne un antigène ayant un degré de conservation élevé, accessible du point de vue immunologique, à la surface d'organismes de Neisseria meningitidis; des compositions immunothérapeutiques, prophylactiques et diagnostiques et des procédés utiles dans le traitement, la prévention et le diagnostic des maladies dues à Neisseria meningitidis; une proteine de surface de Neisseria meningitidis résistant à la proteinase K et ayant une poids moléculaire apparent de 22 kDa; les séquences correspondantes de nucléotides et d'aminoacides dérivés (SEQ ID : 1, 3, 5 et 7; 2, 4, 6 et 8); des procédés fondés sur l'ADN recombinant pour la production de la proteine de surface de Neisseria meningitidis de 22 kDa, et des anticorps qui se lient à elle.
Brodeur Bernard
Hamel Josee
Martin Denis
Rioux Clement
Biochem Vaccines Inc.
Id Biomedical Corporation
Smart & Biggar
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