Proteins and nucleic acids

Details Proteins and nucleic acids Proteins and nucleic acids

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/48 (2006.01) A61K 38/58 (2006.01) C07K 7/64 (2006.01) C07K 14/315 (2006.01) C07K 14/815 (2006.01) C07K 19/00 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 9/48 (2006.01) C12N 9/68 (2006.01) C12N 9/70 (2006.01) C12N 9/72 (2006.01) C12N 15/15 (2006.01) C12N 15/58 (2006.01) C12N 15/81 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2069105

P15586WO ABSTRACT FUSION PROTEINS Relatively inactive fusion proteins are activatable by enzymes of the clotting cascade to have fibrinolytic and/or clot formation inhibition activity. For example, a fusion protein comprising two hirudin or streptokinase molecules, linked by a cleavable linkage sequence, may be cleaved to yield anti-thrombotic hirudin or fibrinolytic streptokinase by thrombin or Factor Xa. Fibrinolytic or clot formation inhibition activity is therefore directed to the site of clot formation.

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