C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/095 (2006.01) C07K 14/22 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2398139
Novel proteins that constitute modified forms of a Neisseria meningitidis surface antigen and encoding nucleic acids are provided. The modified surface proteins are characterized by having deletions of non-conserved amino acids, and thereby being capable of eliciting cross-protective immune responses against Neisseria meningitidis. The invention extends to the use of the modified surface antigens in diagnostics, in therapeutic and prophylactic vaccines and in the design and/or screening of medicaments. The modified surface antigens are particularly usefulin vaccines which effectively immunize against a broader spectrum of N. meningitidis strains than would be expected from a corresponding wild-type surface antigen.
L'invention porte sur de nouvelles protéines qui constituent des formes modifiées d'un antigène de surface <i>Neisseria meningitidis</i> et sur des acides nucléiques les codant. Les protéines de surface modifiées se caractérisent en ce qu'elles possèdent des délétions d'acides aminés non conservés et sont donc capables d'éliciter des réponses immunes à protection croisée et dirigées contre <i>Neisseria meningitidis</i>. L'invention porte également sur l'utilisation des antigènes de surface modifiés dans les diagnostics, dans les vaccins thérapeutiques et prophylactiques et dans la conception et/ou le criblage de médicaments. Les antigènes de surface modifiés sont notamment utiles dans des vaccins qui immunisent efficacement contre un plus large spectre de souches de <i>N. meningitidis</i> que ne le ferait un antigène de surface correspondant du type sauvage.
Jennings Michael Paul
Peak Ian Richard Anselm
Deeth Williams Wall Llp
The University Of Queensland
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