Proteins deposited onto sparingly soluble biocompatible...

Details Proteins deposited onto sparingly soluble biocompatible... Proteins deposited onto sparingly soluble biocompatible...

A - Human Necessities

61

K

A61K 9/14 (2006.01) A61K 9/19 (2006.01)

Patent

CA 2405030

The present invention relates to compositions and methods for the modulated release of one or more proteins or peptides. The composition is comprised of a biocompatible polymeric matrix, a protein and/or peptide, and a sparingly water-soluble or essentially insoluble particle. The protein is deposited by adsorption or some other mechanism onto the sparingly water-soluble biocompatible particle wherein the protein-particle combination is dispersed within the polymeric matrix. The deposition of the protein onto the particle acts to modulate the release of the protein or peptide from dosage forms including long-acting dosage systems.

La présente invention concerne des compositions et des procédés permettant la libération modulée d'une ou plusieurs protéines ou peptides. La composition est constituée d'une matrice polymère biocompatible, d'une protéine et/ou d'un peptide, ainsi que d'une particule modérément hydrosoluble ou sensiblement insoluble. La protéine est déposée par adsorption ou par une autre mécanisme sur la particule biocompatible modérément hydrosoluble, la combinaison protéine-particule étant dispersée dans la matrice polymère. Le dépôt de la protéine sur la particule permet de moduler la libération de la protéine ou du peptide à partir de formes posologiques, comprenant les systèmes posologiques à action prolongée.

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