C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/34 (2006.01) A61K 39/12 (2006.01) C07K 14/01 (2006.01) C07K 16/08 (2006.01) C12Q 1/70 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2380833
The present invention relates to the isolation and characterization of four major proteins derived from White Spot Syndrom Virus (WSSV) having an estimated size of 28 kDa (VP28), 26 kDa (VP26), 24 kDa (VP24) and 19 kDa (VP19) and their use in the manufacture of a vaccine to protect crustaceans against infections with WSSV. The invention further provides for nucleotide sequences encoding said proteins and their use in recombinant production of said proteins. In addition the invention provides for antibodies raised against said proteins, their use in passive vaccination and diagnostic kits comprising said nucleic acids or said antibodies.
L'invention concerne l'isolement et la caractérisation de quatre protéines principales issues du virus de la maladie des points blancs dont la taille est estimée à 28 kDa (VP28), 26 kDa (VP26), 24 kDa (VP24) et 19 kDa (VP19) ainsi que leur utilisation dans l'obtention d'un vaccin visant à protéger les crustacés des infections dues au virus de la maladie des points blancs. L'invention concerne aussi des séquences nucléotidiques codant pour ces protéines, leur utilisation dans la production recombinante de ces protéines ainsi que des anticorps agissant contre ces protéines, leur utilisation dans la vaccination passive et les kits de diagnostic comprenant ces acides nucléiques ou ces anticorps.
Van Hulten Maria Cornelia Wilhelmina
Vlak Justinus Maria
Akzo Nobel N.v.
Fetherstonhaugh & Co.
Intervet International B.v.
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