Proteins that bind angiogenesis-inhibiting proteins,...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/12 (2006.01) A61K 38/00 (2006.01) A61P 9/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07K 14/505 (2006.01) C07K 14/705 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/18 (2006.01) C12Q 1/00 (2006.01) G01N 33/00 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01) A61K 35/76 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2353521

The present invention relates to peptides and proteins such as receptors that bind angiogenesis-related proteins Angiostatin protein and/or Endostatin protein. Peptides and proteins of the present invention can be isolated from body fluids including blood or urine, or can be synthesized by recombinant, enzymatic or chemical methods. The peptides are particularly important for identifying receptors of angiogenesis-related proteins, as well as for identifying other proteins that regulate, transport and otherwise interact with angiogenesis-related proteins. The present invention in particular relates to laminin protein as a putative receptor for Angiostatin protein and tropomyosin as a putative Endostatin protein.

La présente invention concerne des peptides et des protéines telles que des récepteurs, capables de fixer des protéines associées à l'angiogénèse, telles que l'angiostatine et/ou l'endostatine. Les peptides et les protéines de l'invention peuvent soit être isolés dans des liquides organiques, y compris le sang et l'urine, soit être synthétisés par des techniques recombinantes, enzymatiques ou chimiques. Ces peptides sont particulièrement importants pour l'identification de récepteurs de protéines associées à l'angiogénèse, mais aussi pour l'identification d'autres protéines qui régulent, transportent ou présentent une autre interaction avec les protéines associées à l'angiogénèse. La présente invention concerne en particulier la laminine, qui est un récepteur de l'angiostatine, et la tropomyosine, récepteur de l'endostatine.

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