C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/52 (2006.01) A61K 38/17 (2006.01) A61K 38/43 (2006.01) C07K 14/435 (2006.01) C07K 14/52 (2006.01) C07K 14/575 (2006.01) C07K 14/745 (2006.01) C11D 3/386 (2006.01) C12N 9/00 (2006.01) C12N 9/54 (2006.01) C12N 15/16 (2006.01) C12N 15/19 (2006.01) C12Q 1/00 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2095852
The invention provides methods for selecting where in the amino acid sequence of a protein to modify in order to obtain protein variants evoking a reduced immunological response, and protein variants subsequently produced. Also compositions containing the variants and their use in especially detergents and in medicine is disclosed.
L'invention se rapporte à des procédés permettant de choisir l'endroit où une modification doit être effectuée dans la séquence d'acides aminés d'une protéine afin que l'on obtienne des variantes de protéines provoquant une réponse immunologique réduite, ainsi qu'à des variantes de protéines produites ultérieurement. On décrit aussi des compositions contenant ces variantes et leur utilisation, plus particulièrement en médecine et dans des détergents.
Mccarthy Tetrault Llp
Novo Nordisk A/s
Novozymes A/s
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