Proteins with factor viii activity, process for their...

C - Chemistry – Metallurgy – 12 – N

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195/39.1, 195/1.

C12N 15/12 (2006.01) A61K 38/37 (2006.01) C07K 14/755 (2006.01) C07K 16/36 (2006.01) C12N 1/00 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341208

A protein having biological activity of Factor VIII, wherein the amino acid sequence of the protein essentially corresponds to the amino acid sequence of Factor VIII except for (a) a deletion of the amino acids Ser-741 through Ser-1637 and a deletion of at least part of the amino acids Lys-713 through Arg-740; (b) optionally a deletion of the amino acids Gln-1638 through Ile-1668, or part of them; and (c) optionally an insertion of a linking group comprising at least one amino acid.

569359

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