C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/52 (2006.01) A61K 38/00 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) C07K 14/00 (2006.01) C07K 14/435 (2006.01) C12N 15/00 (2006.01) C12N 15/01 (2006.01) C12P 21/02 (2006.01)
Patent
CA 2070171
ABSTRACT OF THE DISCLOSURE The present invention is directed to biologically mutant forms of the cell growth regulatory factor Oncostatin M. The Oncostatin M mutants of the invention comprise deletion, substitution and insertion mutants and may be prepared using recombinant DNA, in vitro mutagenesis and heterologous expression techniques. Oncostatin M mutants may be useful in eliciting Oncostatin M biological responses and, as such, may find a variety of therapeutic uses including but not limited to the treatment of neoplasias.
Kallestad Jeffrey C.
Linsley Peter S.
Oncogen Limited Partnership
Osler Hoskin & Harcourt Llp
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