C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 39/395 (2006.01) C07K 14/20 (2006.01) C07K 16/12 (2006.01) C07K 17/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2486345
The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
L'invention porte sur trois molécules d'ADN isolées qui codent pour les protéines BigL1, BigL2 et BigL3 dans la bactérie Leptospira, ces protéines ayant des domaines de répétition de bactérie, type Ig, et sur leur utilisation dans des applications diagnostiques, thérapeutiques et de vaccination. Selon cette invention, les molécules isolées codant pour les protéines BigL1, BigL2 et BigL3 sont utilisées dans le diagnostic et la prévention d'infection par l'espèce Leptospira qui est capable de générer des maladies chez l'homme et autres mammifères, y compris celles à caractère vétérinaire.
Barocchi Michele
Croda Julio Henrique Rosa
Haake David A.
Ko Albert I.
Matsunaga James
Cornell Research Foundation Inc.
Fiocruz Fundacao Oswaldo Cruz
Kirby Eades Gale Baker
The Regents Of The University Of California
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