Proteoglycan degrading mutants for treatment of cns

Details Proteoglycan degrading mutants for treatment of cns Proteoglycan degrading mutants for treatment of cns

C - Chemistry, Metallurgy

12

N

C12N 15/60 (2006.01) A61K 31/7088 (2006.01) A61K 38/46 (2006.01) A61K 38/47 (2006.01) A61K 38/51 (2006.01) A61K 48/00 (2006.01) C12N 9/14 (2006.01) C12N 9/26 (2006.01) C12N 9/88 (2006.01) C12N 15/55 (2006.01) C12N 15/56 (2006.01)

Patent

CA 2525784

The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous system ("CNS") injury or disease.

La présente invention concerne la préparation et la délétion de mutants de chondroitinases ainsi que leur utilisation dans des méthodes destinées à favoriser la diffusion d'une composition thérapeutique dans les tissus et leur utilisation pour la réhabilitation fonctionnelle neurologique après une lésion ou une maladie du système nerveux central (SNC).

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