C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/19 (2006.01) A61K 38/19 (2006.01) C07K 14/52 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2518248
The invention relates to an endothelial growth factor (VEGF) in which the alanine at AS position 111 is replaced by proline and the arginine at AS position 110 can be substituted by another amino acid. The invention also relates to derivatives of the inventive VEGF, nucleic acids, expression systems, medicaments, and the use of the VEGF mutants of the invention for treating chronic wounds.
L'invention concerne un facteur de croissance VEGF dans lequel l'alanine en position-AS 111 est remplacée par la proline, l'arginine en position-AS 110 pouvant alors être remplacée par un autre acide aminé. L'invention concerne également des dérivés du facteur de croissance VEGF selon l'invention, des acides nucléiques, des systèmes d'expression, des médicaments et l'utilisation des mutants du facteur de croissance VEGF selon l'invention pour traiter des blessures chroniques.
Eming Sabine
Krieg Thomas
Lauer Gereon
Sollberg Stephan
Bayer Innovation Gmbh
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Universitaet Zu Koeln
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