C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/37 (2006.01) C07D 249/04 (2006.01) C12N 9/50 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2567443
Activity-based compositions for analyzing metalloproteases are disclosed, where the compositions include a chemical compound including a hydroxamate moiety and a benzophenone moiety. Methods for synthesizing these compounds are also disclosed, as well as methods of using them for determining the bioactivity of a compositions comprising active compounds toward a metalloproteases and for determining the potency of an inhibitor against a metalloprotease.
L'invention porte: sur des compositions actives d'analyse de métalloprotéases, comprenant un composé chimique présentant un fragment d'hydroxamate et un fragment de benzophénone, sur les procédés de synthèse de tels composés et sur leurs procédés d'utilisation pour déterminer la bioactivité de compositions les contenant vis-à-vis des métalloprotéases et le pouvoir d'un inhibiteur contre les métalloprotéases.
Cravatt Benjamin F.
Jessani Nadim
Joseph Arul
Saghatelian Alan
Mbm Intellectual Property Law Llp
The Scripps Research Institute
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