G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01)
Patent
CA 2667357
The invention concerns the identification of proteomes of biological fluids and their use in determining the state of maternal/fetal conditions, including maternal conditions of fetal origin, chromosomal aneuploidies, and fetal diseases associated with fetal growth and maturation. In particular, the invention concerns a comprehensive proteomic analysis of human amniotic fluid (AF) and cervical vaginal fluid (CVF), and the correlation of characteristic changes in the normal proteome with various pathologic maternal/fetal conditions, such as intra-amniotic infection, pre-term labor, and/or chromosomal defects. The invention further concerns the identification of biomarkers and groups of biomarkers that can be used for non-invasive diagnosis of various pregnancy-related disorders, and diagnostic assays using such biomarkers.
L'invention concerne l'identification de protéomes de fluides biologiques et leur utilisation pour déterminer l'état des conditions maternelles/foetales, y compris des conditions maternelles d'origine foetale, des aneuploïdies chromosomiques et des maladies foetales associées à une croissance et une maturation foetales. En particulier, l'invention concerne une analyse protéomique compréhensive d'un liquide amniotique humain (AF) et d'un liquide cervical-vaginal (CVF), et la corrélation de changements caractéristiques dans le protéome normal avec différentes conditions maternelles/foetales pathologiques, comme une infection intra-amniotique, un travail avant terme et/ou des défauts chromosomiques. L'invention concerne en outre l'identification de biomarqueurs et des groupes de biomarqueurs qui peuvent être utilisés pour un diagnostic non invasif de troubles divers en rapport avec la gestation, et des dosages de diagnostic utilisant de tels biomarqueurs.
Gravett Mike
Nagalla Srinivasa
Rosenfeld Ron
Hologic Inc.
Proteogenix Inc.
Smart & Biggar
LandOfFree
Proteomic analysis of biological fluids does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Proteomic analysis of biological fluids, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proteomic analysis of biological fluids will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1482297