Proteomic profiling method useful for condition diagnosis...

Details Proteomic profiling method useful for condition diagnosis... Proteomic profiling method useful for condition diagnosis...

G - Physics

01

N

G01N 25/20 (2006.01) G01N 33/483 (2006.01)

Patent

CA 2674194

A method of diagnosing or monitoring a condition of interest in a subject includes comparing thermograms generated using differential scanning calorimetery. A signature thermogram contains a protein composition pattern for a sample obtained from the subject. The signature thermogram is compared to a standard thermogram. Standard thermograms can include a negative standard thermogram containing a protein composition pattern associated with an absence of the condition of interest, and a positive standard thermogram containing a protein composition pattern associated with a presence of the condition of interest.

L'invention concerne une méthode de diagnostic ou de surveillance d'un état pathologique étudié chez un sujet, qui consiste à comparer des thermogrammes obtenus par analyse calorimétrique différentielle. Un thermogramme de signature contient un modèle de composition protéique pour un échantillon prélevé sur le sujet. On compare ce thermogramme de signature à un thermogramme standard. Parmi les thermogrammes standard peuvent figurer un thermogramme standard négatif contenant un modèle de composition protéique associé à une absence de l'état pathologique étudié et un thermogramme standard positif contenant un modèle de composition protéique associé à une présence de l'état pathologique étudié.

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