Prothrombin derivatives

Details Prothrombin derivatives Prothrombin derivatives

C - Chemistry, Metallurgy

12

N

C12N 9/74 (2006.01) A61K 38/48 (2006.01) G01N 33/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2224634

The invention relates to novel prothrombin mutants or derivatives thereof having one or more changes in the protein sequence as against the natural protein, are either inactive or have an activity of 10 % at the most and preferably no more than 0.25 % of the natural protein and have a bonding capacity to natural ligands (natural or artificial anticoagulants) essentially corresponding to that of the natural protein. The description also relates to the use of mutated prothrombin mutants or derivatives as pharmaceutical preparations.

L'invention concerne de nouveaux mutants ou dérivés de prothrombine qui présentent, par rapport à la protéine naturelle, une ou plusieurs modifications dans la séquence de protéine, sont soit inactifs, soit présentent une activité d'environ 10 % maximum, de préférence environ 0,25 % maximum de la protéine naturelle, et possèdent une capacité de liaison par rapport aux ligands naturels (anticoagulants naturels ou artificiels), laquelle correspond sensiblement à celle de la protéine naturelle. L'invention décrit également l'utilisation de mutants ou de dérivés de prothrombine mutés comme préparations pharmaceutiques.

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