C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/58 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07F 9/40 (2006.01) C07F 9/6558 (2006.01) C07F 9/6561 (2006.01)
Patent
CA 2394654
Compounds and methods of treating or preventing bone disorders including osteoporosis, rheumatoid arthritis, and metastatic bone disease are provided. The inventive compounds comprise a bone targeting moiety and a payload. The payload portion of these inventive compounds inhibit the proton pump of osteoclasts, thereby, reducing bone resorption. Compounds of the present invention include compounds of formula (I).
L'invention concerne des composés et des méthodes de traitement ou de prévention de troubles osseux, y compris l'ostéoporose, la polyarthrite rhumatoïde, et la maladie osseuse métastatique. Les composés de l'invention comprennent un fragment de ciblage du système osseux et une charge utile. La partie de charge utile de ces composés inhibent la pompe à protons des ostéoclastes, réduisant ainsi la résorption osseuse. Les composés de la présente invention comprennent des composés représentés par la formule (I).
Dalgarno David C.
Iuliucci John
Keenan Terence P.
Sawyer Tomi K.
Weigele Manfred
Ariad Pharmaceuticals Inc.
Borden Ladner Gervais Llp
LandOfFree
Proton pump inhibitors does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Proton pump inhibitors, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Proton pump inhibitors will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1846948