Protonated/acidified nucleic acids and methods of use

Details Protonated/acidified nucleic acids and methods of use Protonated/acidified nucleic acids and methods of use

C - Chemistry, Metallurgy

07

H

C07H 21/00 (2006.01) A01N 43/04 (2006.01) A01N 57/16 (2006.01) A61B 17/04 (2006.01) A61F 13/00 (2006.01) A61K 9/08 (2006.01) A61K 9/14 (2006.01) A61K 31/70 (2006.01) A61K 31/7125 (2006.01) A61K 47/12 (2006.01) A61K 51/00 (2006.01) A61L 15/16 (2006.01) A61P 31/02 (2006.01) A61P 31/04 (2006.01) C07H 19/00 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01) C12N 15/09 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2358570

The novel discovery that protonated nucleic acids inhibit bacterial growth is reported and methods for the preparation and therapeutic use of nuclease resistant and acid resistant protonated/acidified nucleic acids for administration to animals including man, to treat or prevent a bacterial infection are described.

On a découvert que les acides nucléiques protonés inhibent la croissance bactérienne. L'invention concerne également des méthodes de préparation et d'utilisation thérapeutique d'acides nucléiques résistants aux nucléases et aux acides, en vue de leur administration à des animaux, dont l'homme, pour traiter ou prévenir une infection bactérienne.

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