Protopanaxadiol and protopanaxatriol and their use as...

A - Human Necessities – 61 – K

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A61K 31/56 (2006.01) A61K 31/335 (2006.01)

Patent

CA 2460620

The invention provides for the use of sapogenin protopanaxadiol and/or sapogenin protopanaxatriol in synergistic combination with another cancer chemotherapeutic in pharmaceutical compositions used in methods of inhibiting the multiplication of cancer cells, and methods of treating cancer in patients, comprising administering to such patients therapeutically and synergistically effective amounts of sapogenin protopanaxadiol and/or sapogenin protopanaxatriol in combination with a chemotherapeutic selected from the group consisting of paclitaxel and mitoxantrone. The cancer cells to be treated may be multi-drug resistant. The cancer cells may, for example, be prostate cancer cells or breast cancer cells.

L'invention concerne l'utilisation de sapogénine du type protopanaxadiol et/ou de sapogénine du type protopanaxatriol, en combinaison à effet de synergie avec un autre agent chimiothérapeutique dans des compositions pharmaceutiques pour le traitement du cancer, au service de techniques visant à inhiber la multiplication des cellules cancéreuses. L'invention concerne également des procédés de traitement contre le cancer, qui consistent à administrer aux patients des quantités efficaces de ces sapogénines, sur le plan des effets thérapeutiques et des effets de synergie, en combinaison avec un agent chimiothérapeutique pouvant appartenir au groupe constitué par paclitaxel et mitoxantrone. Les cellules cancéreuses à traiter peuvent avoir une résistance pléiotrope. A titre d'exemple, il peut s'agir de cellules propres au cancer de la prostate ou au cancer du sein.

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