Protopanaxadiol and protopanaxatriol and their use as...

Details Protopanaxadiol and protopanaxatriol and their use as... Protopanaxadiol and protopanaxatriol and their use as...

A - Human Necessities

61

K

A61K 45/06 (2006.01) A61K 31/56 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2390290

The invention provides for the use of sapogenin protopanaxadiol and/or sapogenin protopanaxatriol in synergistic combination with another cancer chemotherapeutic in pharmaceutical compositions used in methods of inhibiting the multiplication of cancer cells, and methods of treating cancer in patients,comprising administering to such patients therapeutically and synergisticallyeffective amounts of sapogenin protopanaxadiol and/or sapogenin protopanaxatriol in combination with a chemotherapeutic selected from the group consisting of paclitaxel and mitoxantrone. The cancer cells to be treated may be multi-drug resistant. The cancer cells may, for example, be prostate cancer cells or breast cancer cells.

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