Prrsv vaccines

Details Prrsv vaccines Prrsv vaccines

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/12 (2006.01) C07K 14/08 (2006.01) C12N 7/01 (2006.01) C12N 7/04 (2006.01) C12N 15/40 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2366072

The invention relates to the field of PRRS viruses and infectious clones obtained from PRRS viruses. Furthermore, the invention relates to vaccines and diagnostic assays obtainable by using and modifying such infectious clones of PRRS viruses. The invention provides a porcine reproductive and respiratory syndrome virus (PRRSV) replicon having at least some of its original PRRSV nucleic acid deleted, said replicon capable of in vivo RNA replication, said replicon further having been deprived of at least some of its original PRRSV nucleic acid and/or having been supplemented with nucleic acid derived from a heterologous micro-organism.

L'invention concerne des virus du SRDP et leurs clones infectieux. D'autre part, l'invention concerne des vaccins et des méthodes diagnostiques pouvant être obtenus par utilisation et modification desdits clones infectieux des virus du SRDP. L'invention porte sur un réplicon du virus du syndrome dysgénésique respiratoire porcin dont au moins certains de ses acides nucléiques SRDP ont été délétés, ledit réplicon étant capable de réplication in vivo de l'ARN, et ayant, par la suite, été privé d'au moins certains de ses acides nucléiques SRDP et/ou complété par des acides nucléiques dérivés d'un micro-organisme hétérologue.

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