C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/20 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 15/12 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01) G01N 33/577 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2351887
The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and androgen-independent prostate tumors. It also provides antibodies to PSCA. Further, methods of detection/diagnosis and treatment, as well as a transgenic animal are provided.
La présente invention a pour objet un nouvel antigène prostatique de surface, baptisé antigène de cellule souche prostatique (PSCA), qui est largement surexprimé à tous les stades du cancer de la prostate, y compris dans les néoplasies prostatiques intraépithéliales (PIN) de haut grade et dans les tumeurs de la prostate liées aux androgènes et non liées aux androgènes. L'invention a aussi pour objet des anticorps du PSCA, des méthodes de détection/diagnostic et de traitement, ainsi qu'un animal transgénique.
Reiter Robert E.
Witte Owen N.
Oyen Wiggs Green & Mutala Llp
The Regents Of The University Of California
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