Psca: prostate stem cell antigen and uses thereof

Details Psca: prostate stem cell antigen and uses thereof Psca: prostate stem cell antigen and uses thereof

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 5/16 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2566516

The invention provides a novel prostate cell-surface antigen, designated Prostate Stem Cell Antigen (PSCA), which is widely over-expressed across all stages of prostate cancer, including high grade prostatic intraepithelial neoplasia (PIN), androgen-dependent and andro-gen-independent prostate tumors. It also provides antibodies to PSCA. Further, methods of detection/diagnosis and treatment, as well as a transgenic animal are provided.

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