Pseudo-half-knot rna formation by hybridization of antisense...

Details Pseudo-half-knot rna formation by hybridization of antisense... Pseudo-half-knot rna formation by hybridization of antisense...

C - Chemistry, Metallurgy

12

Q

C12Q 1/70 (2006.01) A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2140669

2140669 9402637 PCTABS00030 Compositions and methods for modulating the activity of RNA are provided. Oligonucleotides are hybridized with an RNA structure to form a stable heteroduplex so that the RNA is no longer recognized by its regulatory protein after oligonucleotide binding. Reactive moieties can be tethered to the oligonucleotide that enhance its activity. Antisense oligonucleotides directed against HIV TAR are provided.

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