C - Chemistry – Metallurgy – 08 – J
Patent
C - Chemistry, Metallurgy
08
J
C08J 3/075 (2006.01) A61K 47/36 (2006.01) C08L 5/08 (2006.01)
Patent
CA 2560432
The composition disclosed is a pseudo-thermosetting neutralized chitosan composition, neutralized with an hydroxylated base, forming a phosphate-free transparent hydrogel at a temperature higher than 5~C. Said composition contains a homogeneously reacetylated chitosan derived from a chitosan having a deacetylation degree of 80 - 90 %, having a molecular weight of not smaller than 200 kDa and a deacetylation degree of 30 - 60 %, and may further contain a diol. Said composition may be used as a drug delivery system.
L'invention concerne une composition de chitosane pseudo-thermodurcissable, neutralisée à l'aide d'une base hydroxylée et qui forme un hydrogel transparent exempt de phosphate à une température supérieure à 5 ·C. Cette composition contient un chitosane réacétylé de manière homogène, dérivé d'un chitosane présentant un degré de désacétylation de 80 - 90 %, présente une masse moléculaire d'au moins 200 kDa et un degré de désacétylation de 30 - 60 % et contient en outre un diol. Cette composition peut servir de système d'apport de médicament.
Berger Jerome
Gurny Robert
Reist Oechslin Marianne
Laboratoire Medidom S.a.
Ridout & Maybee Llp
Universite de Geneve
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