Pseudo-type retroviral vectors with modifiable surface...

Details Pseudo-type retroviral vectors with modifiable surface... Pseudo-type retroviral vectors with modifiable surface...

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 48/00 (2006.01) C07K 16/32 (2006.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2311641

The invention relates to pseudo-typed retroviral vectors having modified surface capsid proteins suitable for cell-specific transduction of a selected mammalian cell type (cell targeting), methods for the preparation of the cell-specific pseudo-typed retroviral vectors and to their use in gene transfer into selected cells.

Vecteurs rétroviraux pseudotypes à protéines de surface d'enveloppe modifiées, qui sont appropriés pour la transduction à spécificité cellulaire d'un type choisi de cellule de mammifère (ciblage cellulaire), ainsi que procédés de fabrication desdits vecteurs et leur utilisation pour le transfert de gènes à des cellules choisies.

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