Pseudodipeptide product possessing an imidazole group and...

C - Chemistry – Metallurgy – 07 – D

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C07D 403/12 (2006.01) A61K 8/49 (2006.01) A61K 8/64 (2006.01) A61K 31/4178 (2006.01) A61K 38/05 (2006.01) C12P 13/24 (2006.01) C12P 17/10 (2006.01) C07D 233/64 (2006.01) C07K 5/06 (2006.01)

Patent

CA 2174526

Pseudodipeptide product of general formula (I), wherein A has: a) either the form (a) in which B is an amine whereof the nitrogen atom directly linked to the carbon atom is selected from amines, imines and ammoniums, } R is a fluorine atom, a fluoroalkyl radical, a functional grouping, an acyl radical, a linear alkyl chain or an alkenyl or aryl radical, } R' is a hydrogen atom, a fluorine atom, an alkyl radical, or a fluoroalkyl radical, and Im is an imidazole or N-substituted imidazole ring; b) or the form (b), in which R is a hydrogen atom or a fluoroalkyl, acyl or hydrocarbon radical which can be substituted by one or more functional groupings, and R" is a hydrocarbon radical or an acyl radical.

Produit pseudodipeptide de formule générale (I) dans laquelle A est: a) soit la forme (a) où B représente une amine dont l'atome d'azote directement lié à l'atome de carbone est choisi parmi les amines, les imines, les ammoniums, .fwdarw. R est un atome de fluor, un radical fluoro-alkyle, un groupement fonctionnel, un radical acyle, une chaîne alkyle linéaire, ou un radical alkényle ou aryle, .fwdarw.R' est un atome d'hydrogène, un atome de fluor, un radical alkyle, ou un radical fluoro- alkyle, et Im est un noyau imidazole ou imidazole N-substitué; b) soit de la forme (b) où R est un atome d'hydrogène ou un radical fluoro- alkyle, acyle ou un radical hydrocarboné pouvant être substitué par un ou plusieurs groupements fonctionnels, et R'' est un radical hydrocarboné ou un radical acyle.

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