Pseudoinfectious flavivirus and uses thereof

Details Pseudoinfectious flavivirus and uses thereof Pseudoinfectious flavivirus and uses thereof

A - Human Necessities

61

K

A61K 39/12 (2006.01) C12N 5/00 (2006.01) C12N 7/00 (2006.01)

Patent

CA 2643819

The present invention discloses a replication-deficient pseudoinfective virus belonging to the Flaviviridae family that lack the capsid gene, where the replication- deficient pseudoinfective virus propagates only in cells expressing the capsid or capsid, prM and envelope protein of the flavivirus. The present also discloses the method of producing such viruses on a large scale and the use of these pseudoinfective viruses as vaccines for preventing diseases caused by infections of humans or animals by the viruses belonging to this family.

La présente invention concerne un virus pseudo-infectieux défectueux de réplication qui appartient à la famille des Flaviviridae, auquel manque le gène de capside, lequel virus pseudo-infectieux défectueux de réplication se propage uniquement dans des cellules qui expriment la capside ou les protéines prM et d'enveloppe de capside du flavivirus. Elle concerne aussi la méthode pour produire de tels virus à grande échelle et pour utiliser lesdits virus pseudo-infectieux comme vaccins pour prévenir des maladies causées par des infections d'êtres humains ou d'animaux par des virus appartenant à cette famille.

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