Pseudomonas aeruginosa and klebsiella virulence genes,...

C - Chemistry – Metallurgy – 07 – H

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C07H 21/02 (2006.01) A61K 39/104 (2006.01) A61K 39/108 (2006.01) A61K 39/395 (2006.01) C07K 14/21 (2006.01) C07K 14/26 (2006.01) C12N 1/20 (2006.01) C12N 1/21 (2006.01) C12Q 1/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2510474

A series of genes from Pseudomonas aeruginosa and Klebsiella are shown to encode products that are implicated in virulence. The identification of theses genes therefore allows attenuated microorganisms to be produced. Furthermore, the genes or their encoded products can be used to identify antimicrobial drugs, diagnostic methods for the identification of a pathogen-associated disease, and in the manufacture of vaccines.

L'invention concerne une série de gènes de Pseudomonas aeruginosa et Klebsiella codant pour des produits associés à la virulence. L'identification de ces gènes permet ainsi de produire des micro-organismes atténués. De plus, ces gènes ou leurs produits codés peuvent être utilisés pour identifier des médicaments antimicrobiens, des méthodes de diagnostic d'identification d'une maladie associée à un agent pathogène, et dans la fabrication des vaccins.

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