Pseudomonas aeruginosa-outer membrane protein pa4710

Details Pseudomonas aeruginosa-outer membrane protein pa4710 Pseudomonas aeruginosa-outer membrane protein pa4710

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 39/104 (2006.01) A61K 39/395 (2006.01) A61P 31/04 (2006.01) C07K 14/21 (2006.01) C07K 16/12 (2006.01) C12N 5/10 (2006.01) G01N 33/569 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2691626

An object is to provide: a protein antigen or a peptide antigen usable as a vaccine composition which has an ability to practically prevent or treat a Pseudomonas aeruginosa infection, and which can cope with the diversity of clinical isolates derived from patients with a Pseudomonas aeruginosa infection; and an antibody directed against the antigen. The present invention provides a protein antigen or a peptide antigen and an antibody directed against these, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa. According to the present invention, a protein or a peptide derived from a Pseudomonas aeruginosa -outer membrane protein PA4710, and an antibody directed against these are provided, which are for use in diagnosis, prevention, or treatment of a disease associated with Pseudomonas aeruginosa.

L'invention concerne un antigène de protéine ou un antigène de peptide qui sont susceptibles de substantiellement prévenir ou traiter une infection à Pseudomonas aeruginosa et peuvent être utilisés en tant que composition de vaccin sensible à diverses souches cliniques isolées chez des patients infectés par Pseudomonas aeruginosa ; et un anticorps dirigé contre l'antigène. L'invention concerne de manière spécifique : un antigène de protéine ou un antigène de peptide qui peuvent être utilisés pour le diagnostic, la prévention ou le traitement d'une maladie associée à Pseudomonas aeruginosa ; et un anticorps dirigé contre l'antigène. L'invention concerne de manière plus spécifique : une protéine ou un peptide dérivés d'une protéine membranaire externe PA0427 de Pseudomonas aeruginosa, qui peuvent être utilisés pour le diagnostic, la prévention ou le traitement d'une maladie associée à Pseudomonas aeruginosa ; et un anticorps dirigé contre la protéine ou lepeptide.

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